Improving the safety and efficacy of warfarin therapy in a metropolitan private hospital: A multidisciplinary practice improvement project

Jed Duff
St Vincent's Private Hospital, Nursing Research Institute, St Vincent's and Mater Health Sydney, Australian Catholic University, Sydney NSW

Kim Walker
Nursing (Applied Research), St Vincent's Private Hospital, Darlinghurst; Nursing Research Institute, St Vincent's and Mater Health Sydney; Australian Catholic University, Sydney NSW

PP: 234 - 244

Abstract

Background: Warfarin is a very complex, high risk therapy and one that carries the potential for severe adverse events. The aim of this project was to improve warfarin management through the application of the best available evidence. The project was undertaken in a 250 bed acute care metropolitan private hospital. Interventions: A suite of evidence-based interventions were used including audit and feedback, patient and provider education, and decision support aides.

Measures: This project used the ongoing collection of warfarin process and outcome clinical indicator data to measure improvement.

Results: Compliance with loading protocol increased by 12% (42-54%); patient education prior to discharge increased by 54% (31-85%); INRs > 5 decreased by 2.6% (3.7-1.1%); and abnormal bleeds fell by 1.2% (1.2-0%).

Conclusion: This multifaceted suite of interventions was successful in influencing clinician behaviour and improving compliance with evidence-based warfarin guidelines.

| More

Keywords

nursing; warfarin; quality and safety; practice improvement; knowledge transfer; multidisciplinary collaboration; statistical process control charts


View references

References

Australian Council on Healthcare Standards [ACHS] (2008) Clinical indicator program information. Ultimo: ACHS.

Benneyan JC, Lloyd RC and Plsek PE (2003) Statistical process control as a tool for research and healthcare improvement. Quality and Safety in Healthcare 12, 458-464.

Bereznicki LR, Jackson SL, Morgan SM, Boland C, Marsden KA, Jupe DM, et al (2007) Improving clinical outcomes for hospital patients initiated on warfarin. Journal of Pharmacy Practice and Research 37(4), 295-302.

Clinical Excellence Commission [CEC] (2006) Analysis of first year of IIMS data annual report 2005-2006. Retrieved 29 September 2008 from http://www.cec.health.nsw.gov.au/pdf/iims_data_AnnualReport.pdf

Clinical Excellence Commission [CEC] (2007a) Medication safety self assessment for antithrombotic therapy [MSSA-AT]. Retrieved 2 June 2008.

Clinical Excellence Commission [CEC] (2007b) Indicators for quality use of medicines in Australian hospitals. Retrieved 2 June 2008 from http://www.ciap.health.nsw.gov.au/nswtag/publications/QUMIndicators/Manual0408.pdf

Dartnell J (2001) Activities to improve hospital prescribing. Australian Prescribe 24(2), 29-31.

Davidson PM, Elliot D and Dolt J (2006) Clinical leadership in contemporary clinical practice: Implications for nursing in Australia. Journal of Nursing Management 14, 180-187.

Department of Health and Aging (2008) Expenditure and prescriptions twelve months to 30 June 2007. Retrieved 29 September 2008 from http://www.sport.gov.au/internet/main/publishing.nsf/Content/pbs-stats-pbexp-jun07

Department of Health and Ageing (2002) The national strategy for quality use of medicine. Canberra: Commonwealth of Australia.

Doran DM and Sidani S (2007) Outcomes-focused knowledge translation: A framework for knowledge translation and patient outcomes improvement. Worldviews on Evidence-Based Nursing 4(1), 3-13.

Duffy ME (2005) Translation research: Its relationship to evidence-based practice. Clinical Nurse Specialist 19(2), 60-62.

Gallus AS, Baker RI, Chong BH, Ockelford PA and Street AM (2000) Consensus guidelines for warfarin therapy: Recommendations from the Australasian society of thrombosis and haemostasis. The Medical Journal of Australia 172(12), 600-605.

Gerrish K and Mawson S (2005) Research, audit, practice development and service evaluation: Implications for research and clinical governance. Practice Development in Health Care 4(1), 33-39.

Ginexi EM and Hilton TF (2006) What's next for translation research? Evaluation and the Health Professions 29(3), 334-347.

Graham ID, Tetroe J and KT Theories research Group (2007) Some theoretical underpinnings of knowledge translation. Academic Emergency Medicine 14, 396-941.

Green LA and Seifert CM (2005) Translation of research into practice: Why we can't 'just do it'. Journal of the American Board of Family Practitioners 18(6), 541-545.

Grimshaw JM, Thomas RE, MacLennan G, Fraser C, Ramsay C and Vale L (2004) Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technology Assessment 8(6): iii-iv, 1-72. Retrieved 2 June 2008 from http://www.hta.nhsweb.nhs.uk

Grol R, Eccles M and Wensing M (2005) Improving patient care: The implementation of change in clinical practice. Edinburgh: Elsevier.

Hirsh J, Guyatt G, Albers GW, Harrington R, Schünemann HJ and for The American College of Chest Physicians (2008) Antithrombotic and thrombolytic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edn). Chest 133(6, Suppl.), 110S-112S.

Hunt E, Sproat S and Kitzmiller R (2004) The nursing informatics implementation guide. Springer Press: New York.

Hutton JL, Eccles MP and Grimshaw JM (2008) Ethical issues in implementation research: A discussion of the problems in achieving informed consent. Implement Science 3, 52.

Institute for Clinical Systems Improvement [ICSI] (2006) Health care guidelines: Anticoagulation therapy supplement. Retrieved 2 June 2008 from http://www.icsi.org/antithrombotic_therapy_supplement__guideline__14045/antithrombotic_therapy_supplement__guideline_.html

Lang ES, Wyer PC and Haynes RB (2007) Knowledge translation: Closing the evidence-to- practice gap. Annals of Emergency Medicine 49(3), 355-363.

Lenfant C (2003) Clinical research to clinical practice - lost in translation? The New England Journal of Medicine 349(9), 868-874.

Liverpool Hospital (2006) Safer systems saves lives: Warfarin management guidelines. Retrieved 2 June 2008 from http://www.cec.health.nsw.gov.au/pdf/SSSL/liverpoolwarfaringuidelinespteducationbooklet06.doc

McCallin A (2003) Interdisciplinary team leadership: A revisionist approach for an old problem? Journal of Nursing Management 11(6), 364-370.

National Health & Research Council [NHMRC] (2000) How to put evidence into practice: Implementation and dissemination strategies. Retrieved 2 June 2008 from http://www.nhmrc.gov.au/publications/synopses/_files/cp71.pdf

National Health Services Scotland (2008) Statistical process control: Tutorial guide. Retrieved 2 June 2008 from http://www.indicators.scot.nhs.uk/SPC/Statistical_Process_Control_Tutorial_Guide_010207.pdf

Newall F, Managle P and Johnston L (2005) Patient understanding of warfarin therapy: A review of education strategies. Hematology 10(6), 437-442.

NSW Department of Health (2003) Easy guide to clinical practice improvement. Retrieved 12 February 2008 from http://www.health.nsw.gov.au/quality/pdf/cpi_easyguide.pdf

Ostini R, Hegney D, Jackson C, Williamson M, Mackson JM, Gurman K, et al (2009) Systematic review of interventions to improve prescribing. Annals of Pharmacotherapy 43, 502-513.

Ousey K (2000) Bridging the theory-practice gap? The role of the lecturer/practitioner in supporting pre-registration students gaining clinical experience in an orthopaedic ward. Journal of Orthopaedic Nursing 4(3), 115-120.

Portney LG and Watkins MP (2009) Foundations of clinical research: Application to practice (3rd edn). Sydney: Pearson.

Rooks JP, Lang G and Kennedy HP (2006) Theory-practice gap in student experiences: Student perceptions of ideal and actual midwifery practice. Journal of Midwifery and Women's Health 51(4), 305-306.

Runciman WB, Roughead EE, Semple SJ and Adams RJ (2003) Adverse drug events and medication errors in Australia. International Journal for Quality in Health Care: Journal of the International Society for Quality in Health Care 15(1), 149-159.

Schünemann HJ, Cook D, Grimshaw J, Liberati A, Heffner J, Tapson V, et al (2004) Antithrombotic and thrombolytic therapy: From evidence to application: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126(3, Suppl.), 688S-696S.

Segaric CA and Hall WA (2005) The family theory-practice gap: A matter of clarity? Nursing Inquiry 12(3), 210-218.

Sussman S, Valente TW, Rohrbach LA, Skara S and Pentz MA (2006) Translation in the health professions: Converting science into action. Evaluation and the Health Professions 29(1), 7-32.

Tooher R, Middleton P, Pham C, Fitridge R, Rowe S, Babidge W, et al (2005) A systematic review of strategies to improve prophylaxis for venous thromboembolism in hospitals. Annals of Surgery 241(3), 397-415.

Walker K (2008) Reading research and scholarship: Critical approaches to effective understanding. In S Borbasi, D Jackson and RW Langford (Eds) Navigating the maze of nursing research: An interactive learning adventure (2nd edn, pp.201-225). Sydney: Elsevier.

Wilson RM and Harrison BT (2003) What is clinical practice improvement? Internal Medicine Journal 32, 460-464.

Wolff A, Taylor S and McCabe F (2004) Using checklists and reminders in clinical pathways to improve hospital inpatient care. Medical Journal of Australia 181(8), 428-431.



RSS Facebook Twitter

Sign Me Up

*Email Address
First Name
Surname

Web Feed

Latest Articles

Special Issues

Advances in Contemporary Health Care for Vulnerable Populations
Volume 42/1
Summary


Advances in Contemporary Community & Family Health Care (3rd edn)
Volume 41/1
Summary | Contents


Advances in Contemporary Complex Health Care: Nursing Interventions
Volume 40/2
Summary | Contents


Advances in Contemporary Community and Family Health Care (2nd edn)
Volume 40/1
Summary | Contents


Advances in Contemporary Nurse Education (2nd edn)
Volume 38/1-2
Summary | Contents


Advances in Contemporary Indigenous Health Care (2nd edn)
Volume 37/1
Summary | Contents


Advances in Contemporary Nursing: Workforce and Workplaces
Volume 36/1-2
Summary | Contents


Advances in Contemporary Modeling of Clinical Nursing Care
Volume 35/2
Summary | Contents


Advances in Contemporary Mental Health Nursing (2nd edn)
Volume 34/2
Summary | Contents


Advances in Contemporary Nursing and Gender
Volume 33/2
Summary | Contents


Advances in Contemporary Nurse Education
Volume 32/1-2
Summary | Contents


Advances in Contemporary Nursing: History of Nursing and Midwifery in Australasia
Volume 30/2
Summary | Contents


crossref.org - The citation linking backbone



Website by Arrowsmith Websites. Website Design Sunshine Coast, Australia.